Health Engineering Group

1. Inflammation ? Cox2
Inflammation: One of the major advances in the understanding of heart disease over the past few years relates to the effect of low-grade inflammation on heart health. As a result, it is increasingly becoming standard practice to test for c-reactive protein (a biomarker for inflammation). This is a prominent risk factor among diabetics, who have a much higher propensity toward heart disease. There are numerous interventions that have been implicated in reducing c-reactive protein. These include vitamin C, vitamin E and omega 3 fatty acids from fish or krill oil. While anti- inflammatory drugs that specifically inhibit the inflammatory enzyme cox-2 may actually increase the risk of heart disease, general anti-inflammatory nutraceuticals like white willow bark have no
negative side effects in relation to the heart.

2. Joint, Muscle, Disc
Joint Care Combo.The years, and an active lifestyle can take their toll on your joints. The secret to healthy joints is to support your joints and their surrounding cartilage, from the inside out, with proven nutrients.

Dr. Sinatra's Joint Care Combo includes both his Joint Solutions and his lemon-flavored Norwegian Fish Oil. Together, they will help ease joint discomfort and build stronger, more flexible joints. Glucosamine Sulfate, Boswellin Serrata Extract, Sea Cucumber Powder, Feverfew Extract (whole herb), White Willow Bark Extract, Yucca Root Powder, Cat's Claw Extract (aerial parts), Bromelain (from pineapple), Shark Cartilage.

What is Inflacain??
Inflacain? is specifically formulated to provide relief from body and joint discomfort associated with pro-inflammatory enzymes. Inflacain? features the most comprehensive and effective blend of natural COX-2 inhibitors available. Modern research implicates COX-2 and other enzymes to be a causative factor for excessive inflammation and many degenerative health challenges.* This botanical blend provides natural, fast-acting and long-lasting joint relief, while being gentle to the lining of the GI tract.

BARBERRY (Berberis vulgaris)
Contains constituents, namely, berberine and kaempfrol, that have been identified as markedly active inhibitors of COX-2.*

BOSWELLIA SERRATA
Blocks the synthesis of pro-inflammatory 5-LO, including 5-HETE and LTB4.*

FEVERFEW (Tanacetum parthenium)
Contains parthenolides, a sesquiterpene lactone, which can inhibit phospholipase A2, platelet aggregation, histamine, and arachidonic acid, increase serotonin release and prostaglandin synthesis.*

GINGER (Zingiber officinalis)
Inhibits both inflammatory COX and 5-LO and offers numerous anti-aging constituents.*

GREEN TEA (Camellia Sinensis)
Contains polyphenols that inhibit the production of arachidonic acid metabolites such as pro- inflammatory prostaglandins and leukotrienes, resulting in a decreased inflammatory response.*

HOLY BASIL (Ocimum sanctum)
Contains ursolic acid, which is a powerful COX-2 inhibitor that significantly reduces inflammation and enhances detoxification.*

ISO-OXYGENE (Patented Hops Extract)
A very powerful and selective COX-2 inhibitor. IsoOxygene has been shown in studies to be a safe and effective natural substance to help in the reduction of inflammation and joint/body discomfort.*

DEVIL'S CLAW (Harpagophytum procumbens)
Contains a iridoid glycoside that exhibits analgesic and anti-inflammatory properties.*

OREGANO (Origanum vulgare)
Contains over 30 known anti-inflammatory compounds, several of which are specific COX-2
inhibitors.*

QUERCETIN
Anti-inflammatory activity appears to be due to its antioxidant capacity, its inhibitory effects on inflammatory-producing enzymes (COX-2 and 5-LO), and subsequent inhibition of inflammatory mediators including leukotrienes and prostaglandins.* ROSEMARY (Rosmarinus officinalis) Inhibits COX-2 and supports detoxification.

RESVERATROL-HU ZHANG (Polygonum cuspidatum)
Inhibits transcription of COX-2, which could also explain resveratrols cancer and inflammatory preventative activity, because the enzyme catalyzes the production of prostaglandins known to suppress the immune activity and to stimulate tumor cell growth.*

SKULLCAP (Scutellaria baicalensis)
This herb has been demonstrated to inhibit lipoxygenase metabolism of arachidonic acid, inhibit COX-2 inflammation, and promote wound healing.*

TURMERIC (Curcurma longa)
A potent anti-inflammatory with specific lipoxygenase- and COX-2-inhibiting properties.*

BROMELAIN
Bromelain is a general name for a family of sulfhydryl proteolytic enzymes obtained from Ananas comosus, the pineapple plant. There are several compelling reasons for supplementation with oral bromelain; It inhibits blood platelet aggregation, favorably modulates prostaglandin formation and minimizes risk of coronary atherosclerotic disease.* It continues to provide a desired physiological action for as long as it is administered, with no evidence indicating that a tolerance develops. It is considered to be non-toxic and lacking in side effects, so it can be used without concern in doses from 200 to 2000 mg for prolonged periods of time. While effective for inflammation and injury, it is even more effective if administered prior to a traumatic event, i.e. surgery or athletic competition.